Across TCGA pan-cancer cohorts, RTL8A mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RTL8A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RTL8A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RTL8A is over-expressed in tumor.

CCRCC and LSCC are the cancer types where RTL8A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RTL8A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.462	.006	2	view →
LSCC	Male	All	+0.334	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: RTL8A RNA expression & survival · all RTL8A data types