Across TCGA patient cohorts, RTL8A mutation is significantly associated with the RNA expression of many other genes, with 681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL8A-associated genes across cancer lineages are FTLP16, ARL5AP1, and RPS27P27. Each is linked with RTL8A in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL8A-to-partner and partner-to-RTL8A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL8A→partner) and Y-score (partner→RTL8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FTLP16 →	+0.087	+3.868	.001	.003	3	2
BRCA	ARL5AP1 →	+0.111	+7.049	<.001	<.001	3	2
UCEC	RPS27P27 →	+0.235	+1.680	<.001	.006	3	2
LUAD	PRAMEF34P →	+0.014	+7.930	<.001	.008	3	2
BRCA	NEK2P1 →	+0.033	+4.506	.001	.009	3	1
BRCA	RNA5SP476 →	+0.325	+5.711	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 681 associations by consensus.

Exploration

RTL8A survival (RNA) · tumor vs normal (RNA) · all RTL8A data types