Across TCGA patient cohorts, RTL8A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL8A-associated genes across cancer lineages are p90 RSK, eIF4G, and JNK_pT183_Y185. Each is linked with RTL8A in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL8A-to-partner and partner-to-RTL8A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL8A→partner) and Y-score (partner→RTL8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.237	+3.321	.001	.009	3	2
UCEC	eIF4G →	+0.248	+2.000	.042	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-2.115	.002	.017	3	1
UCEC	Ku80 →	+0.244	+3.594	.008	.001	3	1
UCEC	mTOR_pS2448 →	-0.117	-3.308	.045	.009	3	1
UCEC	Notch1 →	+0.236	+3.920	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

RTL8A survival (RNA) · tumor vs normal (RNA) · all RTL8A data types