Across TCGA patient cohorts, RTL6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL6-associated genes across cancer lineages are ERK2, INPP4B, and Mre11. Each is linked with RTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL6-to-partner and partner-to-RTL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL6→partner) and Y-score (partner→RTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.261	+3.459	.002	.005	3	1
UCEC	INPP4B →	-0.287	-3.169	.048	.018	3	1
UCEC	Mre11 →	-0.088	-2.700	.022	.006	3	1
UCEC	N-Ras →	-0.125	-1.986	.020	.032	3	1
UCEC	PARP_cleaved →	-0.277	-3.321	.046	.010	3	1
UCEC	P-Cadherin →	-0.192	-3.449	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

RTL6 survival (RNA) · tumor vs normal (RNA) · all RTL6 data types