RTL5

Across TCGA patient cohorts, RTL5 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL5-associated genes across cancer lineages are eEF2, MEK1, and ASNS. Each is linked with RTL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL5-to-partner and partner-to-RTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RTL5-low versus RTL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL5→partner) and Y-score (partner→RTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.232	+1.700	.039	.040	3	2
COAD	MEK1 →	+0.330	+2.824	.001	.034	3	2
UCEC	ASNS →	+0.365	+1.906	.001	.014	3	2
UCEC	ATM →	-0.442	-2.308	.001	.005	3	2
UCEC	Di-Ras3 →	-0.127	-1.584	.006	.005	3	2
UCEC	EGFR_pY1068 →	-0.242	-1.584	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eEF2 by RTL5 expression — UCEC

Explore this box plot interactively →