RTL5

Across TCGA cell cohorts, RTL5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTL5-associated genes across cancer lineages are PNMA6F, TAAR6, and OR5P3. Each is linked with RTL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL5-to-partner and partner-to-RTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNMA6F grouped by RTL5-low versus RTL5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL5→partner) and Y-score (partner→RTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PNMA6F →	+0.006	+4.887	.009	.009	3	1
BLOOD_Leukemia	TAAR6 →	+0.012	+4.922	.001	.009	3	1
BLOOD_Leukemia	OR5P3 →	+0.111	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM47A →	+0.041	+4.922	<.001	.009	3	1
LARGE_INTESTINE	IL20 →	+0.196	+3.662	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PNMA6F by RTL5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →