Across TCGA cell cohorts, RTL4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RTL4-associated genes across cancer lineages are ACER1, OR13D1, and OOSP2. Each is linked with RTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL4-to-partner and partner-to-RTL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL4→partner) and Y-score (partner→RTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACER1 →	+0.069	+4.044	<.001	.009	3	1
LUNG_SCLC	OR13D1 →	+0.043	+4.269	<.001	.005	3	1
LARGE_INTESTINE	OOSP2 →	+0.016	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR9Q2 →	+0.062	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	LRRC53 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NXNL1 →	+0.052	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

RTL4 survival (RNA) · tumor vs normal (RNA) · all RTL4 data types