RTL1

Across TCGA pan-cancer cohorts, RTL1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RTL1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RTL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RTL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and ACC are the cancer types where RTL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.141	0.904	<.001	36	view →
UCEC	DFS	Median	All	0.825	0.626	.003	32	view →
ACC	OS	Median	All	0.245	0.809	<.001	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
STAD	OS	Median	II,III,IV	0.169	0.569	.020	12	view →
OV	DFS	Median	All	0.132	0.541	.001	6	view →
BLCA	DFS	Median	III,IV	0.184	0.472	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RTL1–KIRP (OS)

Open the KIRP breakdown →