RTKN2

Across TCGA patient cohorts, RTKN2 mutation is significantly associated with the RNA expression of many other genes, with 1,738 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTKN2-associated genes across cancer lineages are MIR4659A, RNA5SP415, and GAGE2E. Each is linked with RTKN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RTKN2-to-partner and partner-to-RTKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4659A grouped by RTKN2-low versus RTKN2-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTKN2→partner) and Y-score (partner→RTKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR4659A →	+0.986	+4.203	<.001	.008	3	3
UCEC	RNA5SP415 →	+0.442	+1.974	<.001	.003	3	3
GBM	GAGE2E →	+0.332	+4.584	<.001	.007	3	2
UCEC	RNVU1-28 →	+0.545	+1.742	<.001	.001	3	2
READ	OR6K5P →	+0.042	+5.257	<.001	.002	3	2
LUSC	ANKRD33B-AS1 →	+0.416	+4.287	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,738 associations by consensus.

MIR4659A by RTKN2 expression — GBM

Explore this box plot interactively →