RTKN2

Across TCGA cell cohorts, RTKN2 mutation is significantly associated with the mutation status of many other genes, with 1,547 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTKN2-associated genes across cancer lineages are GJA8, ABHD14A-ACY1, and ARHGAP17. Each is linked with RTKN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RTKN2-to-partner and partner-to-RTKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA8 grouped by RTKN2-low versus RTKN2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTKN2→partner) and Y-score (partner→RTKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GJA8 →	+4.977	+4.415	.007	.007	1	3
BLOOD_Leukemia	ABHD14A-ACY1 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	ARHGAP17 →	+4.479	+5.635	<.001	<.001	1	3
BLOOD_Leukemia	MASP2 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	RABGGTA →	+4.894	+5.870	<.001	<.001	1	3
BLOOD_Leukemia	SLC25A13 →	+4.894	+4.894	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,547 associations by consensus.

GJA8 by RTKN2 expression — OVARY

Explore this box plot interactively →