RTKN2

Across TCGA cell cohorts, RTKN2 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTKN2-associated genes across cancer lineages are Dasatinib, AKT inhibitor VIII, and GSK690693. Each is linked with RTKN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTKN2-to-partner and partner-to-RTKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dasatinib grouped by RTKN2-low versus RTKN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTKN2→partner) and Y-score (partner→RTKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Dasatinib →	+0.562	+2.807	.010	.046	3	1
LARGE_INTESTINE	AKT inhibitor VIII →	+0.588	+3.067	.011	.009	3	1
LARGE_INTESTINE	GSK690693 →	+0.566	+3.067	.013	.009	3	1
LARGE_INTESTINE	Voxtalisib →	+0.314	+2.807	.012	.032	3	1
LARGE_INTESTINE	FY012 →	+0.606	+2.871	.001	.021	2	1
LARGE_INTESTINE	CP724714 →	+0.511	+3.067	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Dasatinib by RTKN2 expression — LARGE_INTESTINE

Explore this box plot interactively →