RTKN

Across TCGA cell cohorts, RTKN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,904 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RTKN-associated GO terms across cancer lineages are Septin cytoskeleton organization, Septin ring organization, and Actomyosin contractile ring organization. Each is linked with RTKN in more than 15 cancer types. Because this analysis shows association rather than direction, both RTKN-to-partner and partner-to-RTKN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Septin cytoskeleton organization grouped by RTKN-low versus RTKN-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RTKN→partner) and Y-score (partner→RTKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Septin cytoskeleton organization →	+0.185	+1.420	<.001	<.001	3	16
BREAST	Septin ring organization →	+0.197	+1.830	<.001	<.001	3	15
OESOPHAGUS	Actomyosin contractile ring organization →	+0.176	+1.350	.001	.001	3	15
KIDNEY	Assembly of actomyosin apparatus involved in cytokinesis →	+0.176	+1.450	.001	<.001	3	12
KIDNEY	Actomyosin contractile ring assembly →	+0.176	+1.450	.001	<.001	3	12
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.180	-1.264	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,904 associations by consensus.

Septin cytoskeleton organization by RTKN expression — PANCREAS

Explore this box plot interactively →