RTKN

Across TCGA cell cohorts, RTKN mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RTKN-associated genes across cancer lineages are MC3R, ACTL9, and OTOP3. Each is linked with RTKN in more than 1 cancer types. Because this analysis shows association rather than direction, both RTKN-to-partner and partner-to-RTKN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC3R grouped by RTKN-low versus RTKN-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTKN→partner) and Y-score (partner→RTKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MC3R →	+0.151	+4.930	<.001	.008	3	1
SOFT_TISSUE	ACTL9 →	+0.299	+4.930	<.001	.008	3	1
SOFT_TISSUE	OTOP3 →	+0.023	+4.930	<.001	.008	3	1
BREAST	OR1L1 →	+0.018	+5.169	.007	.005	3	1
BREAST	OR2T2 →	+0.012	+5.169	<.001	.005	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MC3R by RTKN expression — SOFT_TISSUE

Explore this box plot interactively →