RTF2

Across TCGA patient cohorts, RTF2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTF2-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with RTF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTF2-to-partner and partner-to-RTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RTF2-low versus RTF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTF2→partner) and Y-score (partner→RTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.224	-2.000	.023	.010	3	1
UCEC	EGFR →	-0.203	-1.584	.001	.036	3	1
UCEC	eIF4E →	+0.212	+3.183	.010	.009	3	1
UCEC	eIF4G →	+0.258	+2.584	.034	.010	3	1
UCEC	ERK2 →	+0.179	+2.000	.018	.030	3	1
UCEC	FoxM1 →	+0.237	+2.000	.019	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by RTF2 expression — UCEC

Explore this box plot interactively →