RTF1

Across TCGA pan-cancer cohorts, RTF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RTF1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RTF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RTF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where RTF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.374	0.979	.003	66	view →
LSCC	DFS	Tertile	All	1.000	0.877	.002	12	view →
CCRCC	DFS	Quartile	III,IV	0.734	1.000	.024	5	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RTF1–HNSC (OS)

Open the HNSC breakdown →