RTF1

Across TCGA cell cohorts, RTF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,264 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RTF1-associated GO terms across cancer lineages are Transcription elongation by RNA polymerase II, Heterochromatin formation, and DNA-templated transcription elongation. Each is linked with RTF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both RTF1-to-partner and partner-to-RTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription elongation by RNA polymerase II grouped by RTF1-low versus RTF1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RTF1→partner) and Y-score (partner→RTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Transcription elongation by RNA polymerase II →	+0.085	+0.893	<.001	<.001	3	20
STOMACH	Heterochromatin formation →	+0.084	+0.846	<.001	<.001	3	18
OVARY	DNA-templated transcription elongation →	+0.083	+1.123	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.091	+0.910	<.001	<.001	3	16
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.086	+0.708	<.001	<.001	3	16
BONE	Negative regulation of cell cycle phase transition →	+0.077	+0.439	.002	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,264 associations by consensus.

Transcription elongation by RNA polymerase II by RTF1 expression — BLOOD_Leukemia

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