RTEL1

Across TCGA pan-cancer cohorts, RTEL1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RTEL1 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher RTEL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RTEL1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM and LSCC are the cancer types where RTEL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.743	0.183	.049	5	view →
LSCC	OS	Quartile	All	0.855	0.636	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

RTEL1–GBM (DFS)

Open the GBM breakdown →