RTEL1

Across TCGA patient cohorts, RTEL1 mutation is significantly associated with the RNA expression of many other genes, with 4,775 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTEL1-associated genes across cancer lineages are ELAC2, DERL2, and HARS2. Each is linked with RTEL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RTEL1-to-partner and partner-to-RTEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELAC2 grouped by RTEL1-low versus RTEL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTEL1→partner) and Y-score (partner→RTEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ELAC2 →	+0.455	+2.643	<.001	.005	3	4
SKCM	DERL2 →	+0.551	+4.214	<.001	<.001	3	4
UCEC	HARS2 →	+0.371	+2.584	<.001	<.001	3	4
UCEC	MND1 →	+0.551	+1.637	.002	.001	3	4
UCEC	CLUH →	+0.467	+2.747	<.001	<.001	3	4
SKCM	INPP5K →	+0.419	+2.472	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,775 associations by consensus.

ELAC2 by RTEL1 expression — SKCM

Explore this box plot interactively →