RTEL1

Across TCGA patient cohorts, RTEL1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTEL1-associated genes across cancer lineages are ATM, ERK2, and INPP4B. Each is linked with RTEL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RTEL1-to-partner and partner-to-RTEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RTEL1-low versus RTEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTEL1→partner) and Y-score (partner→RTEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.499	-2.000	<.001	<.001	3	3
UCEC	ERK2 →	+0.152	+1.222	.014	.035	3	2
UCEC	INPP4B →	-0.217	-1.847	.038	.007	3	2
UCEC	JNK2 →	+0.274	+2.933	<.001	<.001	3	2
UCEC	NF2 →	+0.208	+1.906	.003	.015	3	2
UCEC	PARP_cleaved →	-0.234	-3.906	.019	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by RTEL1 expression — UCEC

Explore this box plot interactively →