RTEL1

Across TCGA cell cohorts, RTEL1 mutation is significantly associated with the RNA expression of many other genes, with 298 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTEL1-associated genes across cancer lineages are GPX6, TARM1, and LZIC. Each is linked with RTEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTEL1-to-partner and partner-to-RTEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX6 grouped by RTEL1-low versus RTEL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTEL1→partner) and Y-score (partner→RTEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPX6 →	+0.016	+4.772	<.001	.002	3	2
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	2
LARGE_INTESTINE	LZIC →	+0.562	+2.502	.001	.005	3	2
LARGE_INTESTINE	C11orf98 →	+0.402	+2.502	.008	.005	3	2
CNS	ATP4A →	+0.083	+3.882	<.001	.006	3	2
BLOOD_Leukemia	EDA →	+0.750	+3.470	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 298 associations by consensus.

GPX6 by RTEL1 expression — CNS

Explore this box plot interactively →