RTCB

Across TCGA pan-cancer cohorts, RTCB Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RTCB data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RTCB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RTCB expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

STAD, PRAD, and UCEC are the cancer types where RTCB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.111	0.730	<.001	36	view →
PRAD	DFS	Median	All	0.617	0.886	.041	6	view →
UCEC	OS	Median	IV	0.346	0.764	<.001	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.726	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RTCB–STAD (OS)

Open the STAD breakdown →