RTCB

Across TCGA pan-cancer cohorts, RTCB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RTCB data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RTCB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RTCB expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

UCEC, COAD, and HNSC are the cancer types where RTCB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.479	1.000	.002	36	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	24	view →
HNSC	OS	Quartile	IV	0.535	0.901	.002	18	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	17	view →
PDAC	DFS	Quartile	All	0.841	0.671	.012	14	view →
LSCC	OS	Median	All	1.000	0.924	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RTCB–UCEC (OS)

Open the UCEC breakdown →