RTCB

Across TCGA patient cohorts, RTCB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RTCB-associated genes across cancer lineages are FoxM1, MSH6, and Rab25. Each is linked with RTCB in more than 1 cancer types. Because this analysis shows association rather than direction, both RTCB-to-partner and partner-to-RTCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RTCB-low versus RTCB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTCB→partner) and Y-score (partner→RTCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.242	+3.000	.039	.036	3	1
UCEC	MSH6 →	-0.523	-2.321	.001	.035	2	1
UCEC	Rab25 →	-0.597	-2.321	<.001	.035	2	1
UCEC	Annexin-1 →	+0.832	+3.189	.001	.010	2	1
SKCM	Chk2 →	+0.297	+3.000	.020	.036	2	1
UCEC	C-Raf →	+0.182	+3.459	.011	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by RTCB expression — SKCM

Explore this box plot interactively →