RTCB

Across TCGA cell cohorts, RTCB mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTCB-associated genes across cancer lineages are OR56A5, OR6F1, and TMIGD1. Each is linked with RTCB in more than 1 cancer types. Because this analysis shows association rather than direction, both RTCB-to-partner and partner-to-RTCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by RTCB-low versus RTCB-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTCB→partner) and Y-score (partner→RTCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
BREAST	OR6F1 →	+0.095	+4.421	<.001	.004	3	1
BREAST	TMIGD1 →	+0.023	+4.672	<.001	.002	3	1
BREAST	SKOR2 →	+0.104	+4.963	<.001	.001	3	1
LARGE_INTESTINE	BAAT →	+0.464	+3.273	<.001	.006	3	1
LARGE_INTESTINE	ARMC3 →	+0.367	+3.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR56A5 by RTCB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →