RTCA

Across TCGA patient cohorts, RTCA mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTCA-associated genes across cancer lineages are MSH2, p62 Lck ligand, and PRAS40_pT246. Each is linked with RTCA in more than 1 cancer types. Because this analysis shows association rather than direction, both RTCA-to-partner and partner-to-RTCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RTCA-low versus RTCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTCA→partner) and Y-score (partner→RTCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.270	-2.990	.012	.036	3	1
UCEC	p62 Lck ligand →	+0.446	+3.179	.003	.010	3	1
UCEC	PRAS40_pT246 →	+0.158	+2.598	.048	.006	3	1
UCEC	Tuberin →	+0.354	+2.817	.004	.036	3	1
UCEC	Caspase-8 →	-0.283	-3.700	.015	.001	3	1
UCEC	eIF4E →	+0.194	+3.000	.048	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MSH2 by RTCA expression — UCEC

Explore this box plot interactively →