RTBDN

Across TCGA patient cohorts, RTBDN mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTBDN-associated genes across cancer lineages are EGFR_pY1068, ACVRL1, and ATM. Each is linked with RTBDN in more than 1 cancer types. Because this analysis shows association rather than direction, both RTBDN-to-partner and partner-to-RTBDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RTBDN-low versus RTBDN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTBDN→partner) and Y-score (partner→RTBDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.324	-3.459	.010	.005	3	1
UCEC	ACVRL1 →	-0.158	-2.321	.021	.035	3	1
UCEC	ATM →	-0.610	-2.321	.007	.035	3	1
UCEC	C-Raf →	+0.269	+2.321	<.001	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.256	-2.308	.002	.036	1	1
UCEC	p62 Lck ligand →	+0.469	+2.321	.004	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by RTBDN expression — UCEC

Explore this box plot interactively →