Across TCGA pan-cancer cohorts, RSU1P3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RSU1P3’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RSU1P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RSU1P3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
BRCA and THCA are the cancer types where RSU1P3 tumor–normal differential expression is most reproducible.