RSU1

Across TCGA patient cohorts, RSU1 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible RSU1-associated genes across cancer lineages are RNU6ATAC42P, MIR6131, and H2AB3. Each is linked with RSU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSU1-to-partner and partner-to-RSU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC42P grouped by RSU1-low versus RSU1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSU1→partner) and Y-score (partner→RSU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6ATAC42P →	+0.356	+3.414	<.001	.006	3	2
BLCA	MIR6131 →	+0.243	+7.640	<.001	.009	3	2
SKCM	H2AB3 →	+0.109	+7.816	<.001	.008	3	1
UCEC	MIR378E →	+0.518	+4.453	<.001	<.001	3	1
UCEC	MIR548AI →	+0.345	+4.928	<.001	.002	3	1
UCEC	ATP6V1E1P2 →	+0.172	+2.755	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

RNU6ATAC42P by RSU1 expression — LUSC

Explore this box plot interactively →