RSRC2

Across TCGA pan-cancer cohorts, RSRC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RSRC2 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RSRC2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RSRC2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and COAD are the cancer types where RSRC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.924	0.625	.005	24	view →
LUAD	OS	Tertile	III,IV	0.848	0.339	.008	19	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.916	.042	18	view →
HNSC	DFS	Tertile	All	0.215	0.810	.014	17	view →
PDAC	DFS	Median	All	0.703	0.880	.007	9	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RSRC2–LSCC (OS)

Open the LSCC breakdown →