RSRC2

Across TCGA patient cohorts, RSRC2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSRC2-associated genes across cancer lineages are eIF4E, FASN, and Annexin-1. Each is linked with RSRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSRC2-to-partner and partner-to-RSRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RSRC2-low versus RSRC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSRC2→partner) and Y-score (partner→RSRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.193	+3.335	.019	.005	3	2
UCEC	FASN →	+0.412	+2.502	.007	.002	3	2
UCEC	Annexin-1 →	+0.605	+2.019	.003	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.688	+2.720	.003	.003	3	2
UCEC	EGFR_pY1068 →	-0.382	-3.700	<.001	.001	3	1
UCEC	FoxM1 →	+0.206	+2.000	.042	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by RSRC2 expression — UCEC

Explore this box plot interactively →