RSRC2

Across TCGA cell cohorts, RSRC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,306 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RSRC2-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Heterochromatin formation, and Regulation of sister chromatid cohesion. Each is linked with RSRC2 in more than 17 cancer types. Because this analysis shows association rather than direction, both RSRC2-to-partner and partner-to-RSRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by RSRC2-low versus RSRC2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RSRC2→partner) and Y-score (partner→RSRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.071	+0.658	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.068	+0.658	<.001	<.001	3	17
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.122	+0.715	<.001	<.001	3	17
URINARY_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.140	+0.884	<.001	<.001	3	16
LUNG_SCLC	Regulation of double-strand break repair →	+0.070	+0.616	<.001	.001	3	16
LUNG_SCLC	Microtubule organizing center organization →	+0.066	+0.471	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,306 associations by consensus.

Negative regulation of gene expression, epigenetic by RSRC2 expression — BONE

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