RSRC2

Across TCGA cell cohorts, RSRC2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RSRC2-associated genes across cancer lineages are CST11, MMP26, and BMP3. Each is linked with RSRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSRC2-to-partner and partner-to-RSRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST11 grouped by RSRC2-low versus RSRC2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSRC2→partner) and Y-score (partner→RSRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CST11 →	+0.151	+4.887	<.001	.009	3	2
SKIN	MMP26 →	+0.026	+6.022	<.001	.001	3	1
LARGE_INTESTINE	BMP3 →	+0.600	+3.684	<.001	.009	3	1
LARGE_INTESTINE	P2RY14 →	+0.019	+3.920	.002	.005	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CST11 by RSRC2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →