RSRC2

Across TCGA cell cohorts, RSRC2 mutation is significantly associated with the mutation status of many other genes, with 2,056 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RSRC2-associated genes across cancer lineages are GTF3C2, MDGA2, and CNGA3. Each is linked with RSRC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RSRC2-to-partner and partner-to-RSRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF3C2 grouped by RSRC2-low versus RSRC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSRC2→partner) and Y-score (partner→RSRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GTF3C2 →	+5.824	+5.824	.002	.002	1	4
SKIN	MDGA2 →	+5.824	+5.824	.002	.002	1	4
SKIN	CNGA3 →	+5.824	+5.824	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	SPATA31D1 →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	ACTN4 →	+3.007	+3.584	.008	.008	1	4
BLOOD_Leukemia	PPL →	+2.572	+4.129	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,056 associations by consensus.

GTF3C2 by RSRC2 expression — SKIN

Explore this box plot interactively →