RSPRY1

Across TCGA pan-cancer cohorts, RSPRY1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RSPRY1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RSPRY1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RSPRY1 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where RSPRY1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSPRY1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.397	<.001	9	view →
LSCC	Female	All	+0.375	<.001	8	view →
COAD	All	III,IV	−0.434	.001	6	view →
PDAC	All	IV	+0.507	.049	1	view →
HNSC	Female	IV	+0.400	<.001	1	view →
CCRCC	All	All	−0.064	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RSPRY1–LUAD

Open the LUAD breakdown →