RSPRY1

Across TCGA patient cohorts, RSPRY1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPRY1-associated genes across cancer lineages are eIF4E, INPP4B, and MEK1. Each is linked with RSPRY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPRY1-to-partner and partner-to-RSPRY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RSPRY1-low versus RSPRY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPRY1→partner) and Y-score (partner→RSPRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.201	+3.013	.034	.018	3	1
UCEC	INPP4B →	-0.286	-2.999	.049	.035	3	1
UCEC	MEK1 →	+0.453	+2.700	.005	.006	3	1
UCEC	Myosin-IIa_pS1943 →	+0.288	+2.013	.001	.018	3	1
UCEC	Myosin-IIa →	+0.266	+3.180	.001	.010	3	1
UCEC	p62 Lck ligand →	+0.539	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by RSPRY1 expression — UCEC

Explore this box plot interactively →