RSPO4

Across TCGA pan-cancer cohorts, RSPO4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RSPO4 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RSPO4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RSPO4 expression acts as an unfavorable survival marker.

LUSC, LUAD, and COAD are the cancer types where RSPO4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.173	0.724	.012	9	view →
LUAD	OS	Median	All	0.016	0.835	<.001	6	view →
COAD	DFS	Median	III,IV	0.263	0.669	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RSPO4–LUSC (OS)

Open the LUSC breakdown →