RSPO4

Across TCGA cell cohorts, RSPO4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RSPO4-associated genes across cancer lineages are CYP2C19, ADIG, and CNGA2. Each is linked with RSPO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO4-to-partner and partner-to-RSPO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP2C19 grouped by RSPO4-low versus RSPO4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO4→partner) and Y-score (partner→RSPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP2C19 →	+0.014	+4.152	.003	.009	3	1
BLOOD_Leukemia	ADIG →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
LARGE_INTESTINE	OR10G7 →	+0.210	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CYP2C19 by RSPO4 expression — BLOOD_Leukemia

Explore this box plot interactively →