RSPO3

Across TCGA pan-cancer cohorts, RSPO3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RSPO3 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RSPO3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RSPO3 expression acts as an unfavorable survival marker.

HNSC, LGG, and LUAD are the cancer types where RSPO3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.187	0.710	.014	12	view →
LGG	DFS	Median	All	0.068	0.833	<.001	6	view →
LUAD	OS	Median	All	0.238	0.697	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RSPO3–HNSC (DFS)

Open the HNSC breakdown →