RSPO2

Across TCGA pan-cancer cohorts, RSPO2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RSPO2 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RSPO2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated RSPO2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ACC, and HNSC are the cancer types where RSPO2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.436	.011	24	view →
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
HNSC	DFS	Median	II,III,IV	0.155	0.612	.019	9	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	6	view →
PRAD	DFS	Median	All	0.617	0.886	.038	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
READ	OS	Median	All	0.527	0.932	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RSPO2–UCEC (DFS)

Open the UCEC breakdown →