RSPH6A

Across TCGA pan-cancer cohorts, RSPH6A RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated RSPH6A data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RSPH6A RNA is associated with better overall survival. In most high-consensus cancer types, elevated RSPH6A expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, ACC, and KICH are the cancer types where RSPH6A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.751	0.569	<.001	100	view →
ACC	OS	Tertile	All	0.608	0.876	<.001	84	view →
KICH	DFS	Quartile	II,III,IV	0.422	1.000	.001	66	view →
UCEC	DFS	Median	IV	0.908	0.477	<.001	36	view →
LIHC	OS	Tertile	All	0.381	0.545	.006	29	view →
LUAD	OS	Median	All	0.451	0.287	.002	26	view →
SCLC	OS	Quartile	All	0.855	0.548	.003	22	view →
LUSC	OS	Quartile	All	0.828	0.733	.006	20	view →
UCS	DFS	Quartile	III,IV	0.675	0.194	.015	18	view →
BLCA	OS	Median	All	0.484	0.325	.029	13	view →
COAD	OS	Tertile	IV	1.000	0.344	.027	10	view →
KIRP	DFS	Quartile	IV	0.700	0.297	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

RSPH6A–HNSC (OS)

Open the HNSC breakdown →