RSPH3

Across TCGA patient cohorts, RSPH3 mutation is significantly associated with the RNA expression of many other genes, with 2,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH3-associated genes across cancer lineages are MIR3121, RNU6-177P, and RNU6-70P. Each is linked with RSPH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RSPH3-to-partner and partner-to-RSPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3121 grouped by RSPH3-low versus RSPH3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH3→partner) and Y-score (partner→RSPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3121 →	+0.542	+5.548	<.001	.004	3	3
HNSC	RNU6-177P →	+0.358	+5.368	<.001	.005	3	2
HNSC	RNU6-70P →	+0.881	+5.578	<.001	.004	3	2
LUSC	RNU4-13P →	+0.334	+6.081	<.001	.002	3	2
SKCM	RPL17P49 →	+0.070	+5.634	<.001	.001	3	2
UCEC	MIR425 →	+0.272	+1.814	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,351 associations by consensus.

MIR3121 by RSPH3 expression — LUSC

Explore this box plot interactively →