RSPH3

Across TCGA cell cohorts, RSPH3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RSPH3-associated genes across cancer lineages are SERPINA7, C1orf158, and BHLHE23. Each is linked with RSPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPH3-to-partner and partner-to-RSPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by RSPH3-low versus RSPH3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH3→partner) and Y-score (partner→RSPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
CNS	BHLHE23 →	+0.022	+5.754	<.001	.002	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1
SKIN	OR10G2 →	+0.023	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SERPINA7 by RSPH3 expression — BLOOD_Myeloma

Explore this box plot interactively →