RSPH10B2

Across TCGA patient cohorts, RSPH10B2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH10B2-associated genes across cancer lineages are ATM, EGFR_pY1068, and p62 Lck ligand. Each is linked with RSPH10B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPH10B2-to-partner and partner-to-RSPH10B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RSPH10B2-low versus RSPH10B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH10B2→partner) and Y-score (partner→RSPH10B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.465	-2.000	.023	.032	3	2
UCEC	EGFR_pY1068 →	-0.252	-3.321	.025	.010	3	1
UCEC	p62 Lck ligand →	+0.351	+2.000	.016	.032	3	1
UCEC	P-Cadherin →	-0.148	-3.169	.022	.018	3	1
UCEC	Annexin-1 →	+0.544	+2.000	.022	.032	3	1
UCEC	Shc_pY317 →	-0.157	-2.700	.021	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by RSPH10B2 expression — UCEC

Explore this box plot interactively →