RSF1

Across TCGA pan-cancer cohorts, RSF1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated RSF1 data layer compared with 27 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher RSF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RSF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, UCEC, and OV are the cancer types where RSF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.068	0.756	<.001	22	view →
UCEC	DFS	Median	II,III,IV	0.890	0.303	.017	16	view →
OV	OS	Median	III,IV	0.082	0.837	<.001	12	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
LIHC	OS	Median	All	0.158	0.566	.002	12	view →
LUSC	OS	Median	II,III,IV	0.501	0.743	<.001	10	view →
LGG	DFS	Median	All	0.219	0.825	.012	3	view →
SCLC	DFS	Median	III,IV	0.137	0.517	.042	3	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RSF1–CESC (OS)

Open the CESC breakdown →