RSF1

Across TCGA pan-cancer cohorts, RSF1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RSF1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RSF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RSF1 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

HNSC, COAD, and GBM are the cancer types where RSF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.166	0.947	.010	31	view →
COAD	DFS	Median	All	1.000	0.886	.020	24	view →
GBM	OS	Tertile	All	0.584	0.254	.002	13	view →
LSCC	DFS	Tertile	All	0.844	0.590	.020	13	view →
PDAC	OS	Quartile	All	0.966	0.629	.016	9	view →
UCEC	DFS	Tertile	All	0.883	1.000	.005	8	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.331	.017	4	view →
CCRCC	DFS	Median	II,III,IV	0.834	0.962	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RSF1–HNSC (OS)

Open the HNSC breakdown →