RSF1

Across TCGA patient cohorts, RSF1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSF1-associated genes across cancer lineages are MEK1, PDCD4, and Caspase-7-cleavedD198. Each is linked with RSF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RSF1-to-partner and partner-to-RSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RSF1-low versus RSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSF1→partner) and Y-score (partner→RSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.419	+1.807	<.001	<.001	3	3
COAD	PDCD4 →	-0.511	-2.313	.007	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.784	+1.827	<.001	.002	3	3
COAD	ASNS →	+0.735	+3.169	<.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.179	-1.378	.016	.008	3	2
UCEC	p62 Lck ligand →	+0.319	+1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MEK1 by RSF1 expression — UCEC

Explore this box plot interactively →