RSBN1

Across TCGA pan-cancer cohorts, RSBN1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RSBN1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where RSBN1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RSBN1 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, CCRCC, and COAD are the cancer types where RSBN1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSBN1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	−0.352	<.001	7	view →
CCRCC	All	All	+0.102	<.001	6	view →
COAD	Female	All	+0.242	<.001	5	view →
LSCC	All	All	+0.089	.005	5	view →
HNSC	All	III,IV	−0.156	.010	4	view →
LUAD	Male	All	+0.101	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RSBN1–PDAC

Open the PDAC breakdown →