RSBN1

Across TCGA patient cohorts, RSBN1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSBN1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and EGFR_pY1068. Each is linked with RSBN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RSBN1-to-partner and partner-to-RSBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RSBN1-low versus RSBN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSBN1→partner) and Y-score (partner→RSBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.347	+3.087	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.704	+4.087	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.265	-1.893	<.001	<.001	3	2
UCEC	eIF4E →	+0.163	+1.893	.012	<.001	3	2
UCEC	FoxM1 →	+0.171	+1.643	.033	.003	3	2
UCEC	mTOR_pS2448 →	-0.112	-1.395	.015	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

4E-BP1 by RSBN1 expression — UCEC

Explore this box plot interactively →