RSAD2

Across TCGA pan-cancer cohorts, RSAD2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RSAD2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RSAD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RSAD2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, BLCA, and KICH are the cancer types where RSAD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSAD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.000	<.001	12	view →
BLCA	All	All	+1.133	.001	10	view →
KICH	All	II,III,IV	−1.493	<.001	7	view →
LUSC	Female	All	−1.510	<.001	6	view →
BRCA	All	All	+1.255	<.001	6	view →
UCEC	All	II,III,IV	−0.765	.012	6	view →
COAD	Female	All	−1.660	<.001	5	view →
THCA	Male	II,III,IV	+0.846	.009	5	view →
KIRC	All	All	+0.503	<.001	4	view →
CHOL	All	All	+1.447	.002	3	view →
READ	Female	All	−1.992	.005	2	view →
LUAD	All	All	−0.515	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RSAD2–HNSC

Open the HNSC breakdown →