Across TCGA patient cohorts, RRP7A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP7A-associated genes across cancer lineages are eIF4E, Caspase-8, and eEF2. Each is linked with RRP7A in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP7A-to-partner and partner-to-RRP7A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP7A→partner) and Y-score (partner→RRP7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.241	+3.700	.014	.001	3	2
UCEC	Caspase-8 →	-0.334	-3.295	.004	.009	3	2
UCEC	eEF2 →	+0.413	+2.584	.013	.011	3	1
UCEC	EGFR_pY1068 →	-0.318	-3.700	.006	.001	3	1
UCEC	ERK2 →	+0.216	+3.169	.016	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-3.169	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

RRP7A survival (RNA) · tumor vs normal (RNA) · all RRP7A data types